pentobarbital will lessen the extent or outcome of alosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.pentobarbital will lessen the level or influence of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is actually a sensitive CYP3A4 substrate. Coadmini